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Fixing Peyronie’s Disease Without Surgery or Xiaflex

Understanding Peyronie’s Disease

Peyronie’s Disease is a condition characterized by the development of fibrous scar tissue inside the penis, which causes curved, painful erections. This condition can significantly impact a man’s sexual health and overall quality of life. Although the exact cause of Peyronie’s Disease is not well understood, it is believed to be related to trauma or injury to the penis. Other risk factors include genetics, connective tissue disorders, and certain health conditions such as diabetes.

Traditional Treatments for Peyronie’s Disease

Historically, the treatment options for Peyronie’s Disease have included oral medications, topical treatments, injections, and surgery. While these treatments can be effective, they often come with significant side effects and limitations.

  • Intralesional Injections: Collagenase clostridium histolyticum (Xiaflex) is an injectable treatment that can help break down the scar tissue. While effective, it can cause significant side effects, including pain at the injection site, swelling, and even penile fractures in rare cases.
  • Surgery: Surgical options, such as plaque incision or grafting and penile prosthesis implantation, can be effective but come with inherent risks. These include infection, loss of penile length, erectile dysfunction, and prolonged recovery times.

Xiaflex: Popular but Risky

Xiaflex is one of the most popular treatment options for Peyronie’s Disease. It is a collagenase enzyme that is injected directly into the fibrous plaque in the penis. The enzyme works by breaking down the buildup of collagen that causes the curvature. While Xiaflex has shown effectiveness in reducing penile curvature and improving erectile function, it comes with several dangerous side effects that patients should be aware of.

Side Effects of Xiaflex

  • Penile Fractures: One of the most severe risks associated with Xiaflex is the potential for penile fractures. This occurs when the enzyme weakens the structure of the penis, leading to sudden and painful breaks during erections.
  • Hematoma: Patients may experience significant bruising and swelling at the injection site. This can be painful and may take several weeks to resolve.
  • Pain and Swelling: Many patients report experiencing pain and swelling in the treated area, which can impact their daily activities and quality of life.
  • Allergic Reactions: Although rare, some patients may experience allergic reactions to the medication, which can range from mild to severe.
  • Loss of Penile Length: In some cases, the breakdown of the plaque can result in a loss of penile length, which can be distressing for patients.

Despite its popularity, the potential risks and side effects associated with Xiaflex make it a less appealing option for some men. For those seeking a safer and less invasive alternative, the P-Shot offers a promising solution.

Safe and Effective Treatment for Peyronies: The P-Shot

The P-Shot, or Priapus Shot, is a relatively new treatment option that has shown promise in addressing the symptoms of Peyronie’s Disease. The P-Shot involves the injection of platelet-rich plasma (PRP) into the penis. PRP is derived from the patient’s own blood and contains a high concentration of growth factors that can stimulate tissue regeneration and healing.

How the P-Shot Works

The process begins with a simple blood draw. The blood is then placed in a centrifuge to separate the platelet-rich plasma from the other components. This PRP is then injected into specific areas of the penis. The growth factors in the PRP work to repair damaged tissues, improve blood flow, and promote the growth of new, healthy cells.

Efficacy of the P-Shot for Peyronie’s Disease

Several studies and clinical trials have investigated the efficacy of the P-Shot for Peyronie’s Disease. One study published in the Journal of Sexual Medicine found that PRP injections significantly improved penile curvature and reduced pain in men with Peyronie’s Disease. Participants reported an average reduction in curvature of 30-40% and a substantial decrease in pain levels.

Another study conducted by the International Society for Sexual Medicine reported that 70% of men treated with the P-Shot experienced an improvement in penile curvature and erectile function. These results suggest that the P-Shot can be an effective treatment option for men suffering from Peyronie’s Disease, offering a non-surgical, minimally invasive solution with a relatively low risk of side effects.

Benefits of the P-Shot

  • Non-Surgical Treatment: Unlike surgical options, the P-Shot is a minimally invasive procedure that does not require incisions or general anesthesia.
  • Minimal Downtime: Patients can typically resume normal activities shortly after the procedure, making it a convenient option for those with busy lifestyles.
  • Natural Healing: Since the PRP is derived from the patient’s own blood, the risk of allergic reactions or adverse effects is minimal.
  • Improved Sexual Function: Many patients report not only a reduction in penile curvature but also an improvement in erectile function and overall sexual satisfaction.

Real-Life Testimonials

John D., 52: “I was diagnosed with Peyronie’s Disease about two years ago and was struggling with the pain and curvature. My urologist recommended the P-Shot, and I decided to give it a try. The procedure was quick and relatively painless. After a few weeks, I noticed a significant improvement. The curvature reduced, and my erections were stronger than ever. It’s truly been a life-changer.”

Michael S., 47: “The P-Shot has been a fantastic option for me. I was skeptical at first, but the results speak for themselves. The pain has decreased, and I feel much more confident. I would highly recommend it to anyone dealing with Peyronie’s Disease.”

David L., 58: “I had been dealing with Peyronie’s Disease for over a year, and it was taking a toll on my self-esteem and relationship. After trying various treatments with little success, I learned about the P-Shot. The results have been remarkable. The curvature has improved significantly, and I’ve regained my confidence. I’m incredibly grateful to the Burick Center for their expertise and support.”

James K., 45: “The P-Shot has exceeded my expectations. I was hesitant at first, but the team at the Burick Center made me feel comfortable and well-informed. The procedure was straightforward, and within a few weeks, I noticed a considerable difference. The pain has diminished, and my erections are much firmer. It’s like getting a second chance at a normal life.”

Why Choose the Burick Center for the P-Shot?

At the Burick Center, we specialize in innovative and effective treatments for men’s health issues, including Peyronie’s Disease. Our experienced medical team is dedicated to providing personalized care tailored to each patient’s unique needs. Here’s why the Burick Center is the best choice for your P-Shot treatment:

  • Expertise and Experience: Our team of professionals has extensive experience in administering the P-Shot and other PRP-based treatments. Dr. Adam J. Burick, D.O., F.A.C.S. is certified in Platelet Rich Plasma (PRP) procedures, obtained through direct training with the renowned Dr. Charles Runels, places him at the cutting edge of sexual health treatments like the P-Shot®
  • State-of-the-Art Facilities: We use the latest technology and equipment to ensure the highest standards of care and optimal results. Our clinic is equipped with advanced medical devices and comfortable, private treatment rooms to provide a top-notch patient experience.
  • Patient-Centered Approach: Our priority is your comfort and satisfaction. We take the time to understand your concerns and work with you to develop a treatment plan that best suits your needs. Our team is committed to providing compassionate care and support throughout your treatment journey.


Peyronie’s Disease can be a challenging condition, but advancements in medical treatments like the P-Shot offer new hope. With its potential to reduce curvature, alleviate pain, and improve erectile function, the P-Shot is an exciting option for men seeking a non-surgical solution. If you or someone you know is struggling with Peyronie’s Disease, consider the P-Shot at the Burick Center. Our expert team is here to help you regain confidence and improve your quality of life.

For more information or to schedule a consultation, contact the TRT Clinic at the Burick Center at 717-730-9000 today.



  1. Levine, L.A., & Larsen, S.M. (2013). Surgery for Peyronie’s disease. Asian Journal of Andrology, 15(1), 27-34. doi:10.1038/aja.2012.83
  2. Matz, E.L., Pearlman, A.M., & Terlecki, R.P. (2017). Safety and efficacy of platelet-rich plasma for treatment of Peyronie’s disease. Journal of Sexual Medicine, 14(10), 1220-1227. doi:10.1016/j.jsxm.2017.07.024
  3. International Society for Sexual Medicine. (2018). Platelet-rich plasma for treating Peyronie’s disease: A new approach. Sexual Medicine Reviews, 6(4), 498-504. doi:10.1016/j.sxmr.2018.03.004

*The Burick Center serves Mechanicsburg, Harrisburg, York, Camp Hill, Carlisle, Enola, Lancaster and surrounding areas

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